@article {Merola2058_2017,
	year = {2017},
	author = {Merola, Aristide and Fasano, Alfonso and Hassan, Anhar and Ostrem, Jill L. and Contarino, Maria Fiorella and Lyons, Mark and Krauss, Joachim K. and Wolf, Marc E. and Klassen, Bryan T. and van Rootselaar, Anne-Fleur and Regidor, Ignacio and Duker, Andrew P. and Ondo, William and Guridi, Jorge and Volkmann, Jens and Shukla, Aparna Wagle and Mandybur, George T. and Okun, Michael S. and Witt, Karsten and Starr, Philip A. and Deuschl, Guenther and Espay, Alberto J.},
	title = {Thalamic Deep Brain Stimulation for Orthostatic Tremor: A Multicenter
   International Registry},
	journal = {MOVEMENT DISORDERS},
	volume = {32},
	number = {8},
	DOI = {10.1002/mds.27082},
	ISSN = {0885-3185},
	publisher = {WILEY},
	keywords = {DBS; orthostatic tremor; Vim; shaky legs; treatment},
	abstract = {Background: We report the accumulated experience with ventral
   intermediate nucleus deep brain stimulation for medically refractory
   orthostatic tremor.
   Methods: Data from 17 patients were reviewed, comparing presurgical,
   short-term (0-48 months), and long-term (>= 48 months) follow-up. The
   primary end point was the composite activities of daily
   living/instrumental activities of daily living score. Secondary end
   points included latency of symptoms on standing and treatment-related
   complications.
   Results: There was a 21.6\% improvement (P = 0.004) in the composite
   activities of daily living/instrumental activities of daily living
   score, which gradually attenuated (12.5\%) in the subgroup of patients
   with an additional long-term follow-up (8 of 17). The latency of
   symptoms on standing significantly improved, both in the shortterm (P =
   0.001) and in the long-term (P = 0.018). Three patients obtained
   no/minimal benefit from the procedure.
   Conclusions: Deep brain stimulation of the ventral intermediate nucleus
   was, in general, safe and well tolerated, yielding sustained benefit in
   selected patients with medically refractory orthostatic tremor. (C) 2017
   International}
}