@article {Kalbe2063_2016,
	year = {2016},
	author = {Kalbe, Elke and Rehberg, Sarah Petra and Heber, Ines and Kronenbuerger, Martin and Schulz, Joerg B. and Storch, Alexander and Linse, Katharina and Schneider, Christine and Graeber, Susanne and Liepelt-Scarfone, Inga and Berg, Daniela and Dams, Judith and Balzer-Geldsetzer, Monika and Hilker, Ruediger and Oberschmidt, Carola and Witt, Karsten and Schmidt, Nele and Mollenhauer, Brit and Trenkwalder, Claudia and Spottke, Annika and Roeske, Sandra and Wittchen, Hans-Ulrich and Riedel, Oliver and Dodel, Richard},
	title = {Subtypes of mild cognitive impairment in patients with Parkinson's
   disease: evidence from the LANDSCAPE study},
	journal = {JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY},
	volume = {87},
	number = {10},
	DOI = {10.1136/jnnp-2016-313838},
	ISSN = {0022-3050},
	publisher = {BMJ PUBLISHING GROUP},
	abstract = {Objective Inconsistent results exist regarding the cognitive profile in
   patients with Parkinson's disease with mild cognitive impairment
   (PD-MCI). We aimed at providing data on this topic from a large cohort
   of patients with PD-MCI.
   Methods Sociodemographic, clinical and neuropsychological baseline data
   from patients with PD-MCI recruited in the multicentre, prospective,
   observational DEMPARK/LANDSCAPE study were analysed.
   Results 269 patients with PD-MCI (age 67.8 +/- 7.4, Unified Parkinson's
   Disease Rating Scale (UPDRS-III) scores 23.2 +/- 11.6) were included.
   PD-MCI subtypes were 39.4\% non-amnestic single domain, 30.5\% amnestic
   multiple domain, 23.4\% non-amnestic multiple domain and 6.7\% amnestic
   single domain. Executive functions were most frequently impaired. The
   most sensitive tests to detect cognitive dysfunctions were the Modified
   Card Sorting Test, digit span backwards and word list learning direct
   recall. Multiple stepwise regression analyses showed that global
   cognition, gender and age, but not education or disease-related
   parameters predicted PD-MCI subtypes.
   Conclusions This study with the so far largest number of prospectively
   recruited patients with PD-MCI indicates that non-amnestic PD-MCI is
   more frequent than amnestic PD-MCI; executive dysfunctions are the most
   typical cognitive symptom in PD-MCI; and age, gender and global
   cognition predict the PD-MCI subtype. Longitudinal data are needed to
   test the hypothesis that patients with PD-MCI with specific cognitive
   profiles have different risks to develop dementia.}
}